Therapeutic drug monitoring of antiepileptic drugs: current status and future prospects
C Johannessen Landmark… - Expert opinion on …, 2020 - Taylor & Francis
ABSTRACT Introduction: Antiepileptic drugs (AEDs) are the cornerstone of treatment of
patients with epilepsy, and there are presently 27 licensed AEDs making AEDs among the …
patients with epilepsy, and there are presently 27 licensed AEDs making AEDs among the …
Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs
PN Patsalos, E Perucca - The Lancet Neurology, 2003 - thelancet.com
There are two types of interactions between drugs, pharmacokinetic and pharmacodynamic.
For antiepileptic drugs (AEDs), pharmacokinetic interactions are the most notable type, but …
For antiepileptic drugs (AEDs), pharmacokinetic interactions are the most notable type, but …
Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE …
PN Patsalos, DJ Berry, BFD Bourgeois, JC Cloyd… - …, 2008 - Wiley Online Library
Although no randomized studies have demonstrated a positive impact of therapeutic drug
monitoring (TDM) on clinical outcome in epilepsy, evidence from nonrandomized studies …
monitoring (TDM) on clinical outcome in epilepsy, evidence from nonrandomized studies …
Clinically significant pharmacokinetic drug interactions with carbamazepine: an update
E Spina, F Pisani, E Perucca - Clinical pharmacokinetics, 1996 - Springer
Carbamazepine is one of the most commonly prescribed antiepileptic drugs and is also
used in the treatment of trigeminal neuralgia and psychiatric disorders, particularly bipolar …
used in the treatment of trigeminal neuralgia and psychiatric disorders, particularly bipolar …
Pharmacokinetic interactions between antiepileptic drugs: clinical considerations
R Riva, F Albani, M Contin, A Baruzzi - Clinical pharmacokinetics, 1996 - Springer
Antiepileptic drug interactions represent a common clinical problem which has been
compounded by the introduction of many new compounds in recent years. Most …
compounded by the introduction of many new compounds in recent years. Most …
Effect of Valproate on Cerebral Metabolism and Blood Flow: An 18F‐2‐Deoxyglusose and 15O Water Positron Emission Tomography Study
We compared the effect of valproate (VPA) on cerebral metabolic rate for glucose (CMRGlc)
and cerebral blood flow (CBF), measured with 18F‐2–deoxyglucose (I8FDG) and 15O water …
and cerebral blood flow (CBF), measured with 18F‐2–deoxyglucose (I8FDG) and 15O water …
[HTML][HTML] Physiologically based pharmacokinetic modeling to predict maternal pharmacokinetics and fetal carbamazepine exposure during pregnancy
Y Chen, M Ke, W Fang, Y Jiang, R Lin, W Wu… - European Journal of …, 2024 - Elsevier
Carbamazepine is an antiepileptic drug commonly used in pregnant women, during which
the physiological changes may affect its efficacy. The aim of this study was to establish a …
the physiological changes may affect its efficacy. The aim of this study was to establish a …
The pharmacokinetics of oxcarbazepine and its active metabolite 10‐hydroxy‐carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or …
A Tartara, CA Galimberti, R Manni… - British journal of …, 1993 - Wiley Online Library
The kinetics of oxcarbazepine (OXC) and its active metabolite 10‐hydroxy‐carbazepine (10‐
OH‐CZ) after a single oral OXC dose (600 mg) were compared in healthy control subjects …
OH‐CZ) after a single oral OXC dose (600 mg) were compared in healthy control subjects …
Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: pooled analysis of data from randomized clinical trials
BD Moseley, C Otoul, L Staelens, A Stockis - Epilepsy Research, 2019 - Elsevier
Objective To assess the effect of brivaracetam (BRV) on steady-state plasma concentrations
of commonly prescribed antiepileptic drugs (AEDs). Methods Data were pooled from five …
of commonly prescribed antiepileptic drugs (AEDs). Methods Data were pooled from five …
A double‐blind, placebo‐controlled study on the effect of vigabatrin on in vivo parameters of hepatic microsomal enzyme induction and on the kinetics of steroid oral …
A Bartoli, G Gatti, G Cipolla, N Barzaghi, G Veliz… - …, 1997 - Wiley Online Library
Purpose: This study was conducted to determine whether vigabatrin affects in vivo indices of
hepatic microsomal enzyme activity and the pharmacokinetics of steroid oral contraceptives …
hepatic microsomal enzyme activity and the pharmacokinetics of steroid oral contraceptives …