The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs)
together with neurons and glial cells, including microglia, forms the neurovascular unit …

Despite dramatic improvements in the management of traumatic brain injury (TBI), to date
there is no effective treatment available to patients, and morbidity and mortality remain high …

In inflammatory diseases occurring outside the CNS, communication between the periphery
and the brain via humoral and/or neural routes results in central neural changes and …

The nature of microglia fascinated many prominent researchers in the 19th and early 20th
centuries, and in a classic treatise in 1932, Pio del Rio-Hortega formulated a number of …

Advances in the management of pediatric brain tumors have increased survival rates in
children, but their quality of life is impaired due to cognitive deficits that arise from irradiation …

Chemokines and their receptors have crucial roles in the trafficking of leukocytes, and are of
particular interest in the context of the unique immune responses elicited in the central …

The chemokine receptor CCR2 plays a vital role for the induction of autoimmunity in the
central nervous system. However, it remains unclear how the pathogenic response is …

Cytokines and microglia have been implicated in anxiety, depression, neurodegeneration as
well as the regulation of alcohol drinking and other consumatory behaviors, all of which are …

Mice lacking the chemokine receptor chemotactic cytokine receptor 2 (CCR2) have a
marked attenuation of monocyte recruitment in response to various inflammatory stimuli and …

The search for immune biomarkers in psychiatric disorders has primarily focused on pro-
inflammatory cytokines. Other immune proteins including chemokines have been relatively …