Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Two types of sequences, proline-rich domains (PRDs) and the WASP-homology 2 (WH2)
domain, are found in most actin filament nucleation and elongation factors discovered thus …

Cytoskeletal structures characterized by actin filaments with uniform lengths, including the
thin filaments of striated muscles and the spectrin-based membrane skeleton, use barbed …

Aerobic (AE) and resistance exercise (RE) elicit unique adaptations in skeletal muscle that
have distinct implications for health and performance. The purpose of this study was to …

Hypertrophic cardiomyopathy is one of the most common inherited cardiomyopathies and a
leading cause of sudden cardiac death in young adults. Despite profound insights into the …

Previous transcriptomic studies have hypothesized the occurrence of slow myofiber-
phenotype, and dysregulation of lipid metabolism as being associated with the development …

The actin cytoskeleton and Rho GTP ase signaling to actin assembly are prime targets of
bacterial and viral pathogens, simply because actin is involved in all motile and membrane …

Actin nucleotide-dependent actin remodeling is essential to orchestrate signal transduction
and cell adaptation. Rapid energy starvation requires accurate and timely reorganization of …

Tropomyosin is the major regulator of the thin filament. In striated muscle its function is to
bind troponin complex and control the access of myosin heads to actin in a Ca 2+ …

Improper lengths of actin-thin filaments are associated with altered contractile activity and
lethal myopathies. Leiomodin, a member of the tropomodulin family of proteins, is critical in …