Remote oxidation of aliphatic C–H bonds in nitrogen-containing molecules
JM Howell, K Feng, JR Clark… - Journal of the …, 2015 - ACS Publications
Nitrogen heterocycles are ubiquitous in natural products and pharmaceuticals. Herein, we
disclose a nitrogen complexation strategy that employs a strong Brønsted acid (HBF4) or an …
disclose a nitrogen complexation strategy that employs a strong Brønsted acid (HBF4) or an …
Cornelian Cherry (Cornus mas L.) Fruit Extract Lowers SREBP-1c and C/EBPα in Liver and Alters Various PPAR-α, PPAR-γ, LXR-α Target Genes in Cholesterol-Rich …
M Danielewski, A Rapak, A Kruszyńska… - International Journal of …, 2024 - mdpi.com
Cornelian cherry (Cornus mas L.) fruits, abundant in iridoids and anthocyanins, are natural
products with proven beneficial impacts on the functions of the cardiovascular system and …
products with proven beneficial impacts on the functions of the cardiovascular system and …
Dammarane triterpenes and phytosterols from Dysoxylum tpongense Pierre and their anti-inflammatory activity against liver X receptors and NF-κB activation
NK Pham, HT Bui, TH Tran, TNA Hoang, TH Vu, DT Do… - Steroids, 2021 - Elsevier
Dysoxylum tpongense Pierre (local name 'Huynh Dan Bap') belonging to family Meliaceae,
is a tree (3–10 m height), distributed in the mountainous areas (ca. 1000 m asl) in North …
is a tree (3–10 m height), distributed in the mountainous areas (ca. 1000 m asl) in North …
ω-3 Fatty acids reverse lipotoxity through induction of autophagy in nonalcoholic fatty liver disease
Y Chen, C Xu, T Yan, C Yu, Y Li - Nutrition, 2015 - Elsevier
Objective The aim of this study was to evaluate the effect of ω-3 fatty acids on nonalcoholic
fatty liver disease concerning hepatocyte lipid accumulation as well as apoptosis induced by …
fatty liver disease concerning hepatocyte lipid accumulation as well as apoptosis induced by …
The LXR ligand T0901317 acutely inhibits insulin secretion by affecting mitochondrial metabolism
J Maczewsky, J Sikimic, C Bauer… - …, 2017 - academic.oup.com
The role of liver X receptor (LXR) in pancreatic β-cell physiology and pathophysiology is still
unclear. It has been postulated that chronic LXR activation in β-cells induces lipotoxicity, a …
unclear. It has been postulated that chronic LXR activation in β-cells induces lipotoxicity, a …
Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors
OAH Åstrand, EÖ Viktorsson, AL Kristensen… - The Journal of steroid …, 2017 - Elsevier
Abstract Liver X Receptor (LXR) modulators have shown potential as drugs since they target
genes affecting metabolism and fatty acid synthesis. LXR antagonists are of particular …
genes affecting metabolism and fatty acid synthesis. LXR antagonists are of particular …
Design and Synthesis of OSW-1 Analogs and Other Bioactive Small Molecules for Potential Therapeutic Applications
A Le - 2018 - shareok.org
OSW-1 is a cholestane glycoside natural product with potent anti-proliferative activity, broad
spectrum anti-viral activity, and a novel mechanism of action. The OSW-1's cellular targets …
spectrum anti-viral activity, and a novel mechanism of action. The OSW-1's cellular targets …
[PDF][PDF] Crystal structure of (S)-2-[(3S, 8S, 9S, 10R, 13S, 14S, 17R)-3-hydroxy-10, 13-dimethyl-2, 3, 4, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17-tetradecahydro-1H …
EØ Viktorsson, OAH Åstrand, RS Haseeb… - Acta …, 2015 - journals.iucr.org
The literature compound 3β-hydroxy-bisnor-5-cholenic aldehyde is an important
intermediate for the synthesis of new modulators of the nuclear oxysterol receptor Liver X. As …
intermediate for the synthesis of new modulators of the nuclear oxysterol receptor Liver X. As …
[引用][C] NAPOVEDOVANJE MOŽNEGA ENDOKRINEGA DELOVANJA UČINKOVIN V ZDRAVILIH, REGISTRIRANIH V REPUBLIKI SLOVENIJI, Z RAČUNALNIŠKIM …
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