AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis
Cells are programmed to favorably respond towards the nutrient availability by adapting
their metabolism to meet energy demands. AMP-activated protein kinase (AMPK) is a highly …
their metabolism to meet energy demands. AMP-activated protein kinase (AMPK) is a highly …
[HTML][HTML] Endoplasmic reticulum stress and liver diseases
X Liu, RM Green - Liver research, 2019 - Elsevier
Endoplasmic reticulum (ER) stress occurs when ER homeostasis is perturbed with
accumulation of unfolded/misfolded protein or calcium depletion. The unfolded protein …
accumulation of unfolded/misfolded protein or calcium depletion. The unfolded protein …
[HTML][HTML] ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis
Background & Aims Hepatocellular carcinoma (HCC), a leading cause of cancer-related
death, is associated with viral hepatitis, non-alcoholic steatohepatitis (NASH), and alcohol …
death, is associated with viral hepatitis, non-alcoholic steatohepatitis (NASH), and alcohol …
[HTML][HTML] Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis
Hepatocytes have important roles in liver iron homeostasis, abnormalities in which are
tightly associated with liver steatosis and fibrosis. Here, we show that non-alcoholic fatty liver …
tightly associated with liver steatosis and fibrosis. Here, we show that non-alcoholic fatty liver …
Hepatitis B virus serum DNA andRNA levels in nucleos (t) ide analog‐treated or untreated patients during chronic and acute infection
EK Butler, J Gersch, A McNamara, KC Luk… - Hepatology, 2018 - journals.lww.com
Abstract Treatment of chronic hepatitis B (CHB) patients with nucleos (t) ide analogs (NAs)
suppresses hepatitis B virus (HBV) DNA synthesis but does not affect synthesis of HBV …
suppresses hepatitis B virus (HBV) DNA synthesis but does not affect synthesis of HBV …
ATF4 activation promotes hepatic mitochondrial dysfunction by repressing NRF1–TFAM signalling in alcoholic steatohepatitis
Objective Mitochondrial dysfunction plays a dominant role in the pathogenesis of alcoholic
liver disease (ALD); however, the underlying mechanisms remain to be fully understood. We …
liver disease (ALD); however, the underlying mechanisms remain to be fully understood. We …
Fat Mass and Obesity Associated (FTO) Gene and Hepatic Glucose and Lipid Metabolism
TM Mizuno - Nutrients, 2018 - mdpi.com
Common genetic variants of the fat mass and obesity associated (FTO) gene are strongly
associated with obesity and type 2 diabetes. FTO is ubiquitously expressed. Earlier studies …
associated with obesity and type 2 diabetes. FTO is ubiquitously expressed. Earlier studies …
Endoplasmic reticulum stress signaling and the pathogenesis of hepatocarcinoma
Hepatocellular carcinoma (HCC), also known as hepatoma, is a primary malignancy of the
liver and the third leading cause of cancer mortality globally. Although much attention has …
liver and the third leading cause of cancer mortality globally. Although much attention has …
[HTML][HTML] FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
H Herrema, D Guan, JW Choi, X Feng… - Cell metabolism, 2022 - cell.com
Chronic endoplasmic reticulum (ER) stress and sustained activation of unfolded protein
response (UPR) signaling contribute to the development of type 2 diabetes in obesity. UPR …
response (UPR) signaling contribute to the development of type 2 diabetes in obesity. UPR …
ATF4 deficiency promotes intestinal inflammation in mice by reducing uptake of glutamine and expression of antimicrobial peptides
X Hu, J Deng, T Yu, S Chen, Y Ge, Z Zhou, Y Guo… - Gastroenterology, 2019 - Elsevier
Background & Aims Activating transcription factor 4 (ATF4) regulates genes involved in the
inflammatory response, amino acid metabolism, autophagy, and endoplasmic reticulum …
inflammatory response, amino acid metabolism, autophagy, and endoplasmic reticulum …