In recent years, powerful genetic code reprogramming methods have emerged that allow
new functional components to be embedded into proteins as noncanonical amino acid …

Biocatalysis harnesses enzymes to make valuable products. This green technology is used
in countless applications from bench scale to industrial production and allows practitioners …

Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR)
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …

Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to
deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing …

The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

Electrons can tunnel through proteins in microseconds with a modest release of free energy
over distances in the 15 to 20 Å range. To span greater distances, or to move faster, multiple …

Aerobic ribonucleotide reductases (RNRs) initiate synthesis of DNA building blocks by
generating a free radical within the R2 subunit; the radical is subsequently shuttled to the …

Fluorochemicals are a widely distributed class of compounds and have been utilized across
a wide range of industries for decades. Given the environmental toxicity and adverse health …

The beginnings of redox biology are recalled with special emphasis on formation,
metabolism and function of reactive oxygen and nitrogen species in mammalian systems …

Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living
organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the conversion of …