Controlled microwave heating in modern organic synthesis: highlights from the 2004–2008 literature

CO Kappe, D Dallinger - Molecular diversity, 2009 - Springer
Direct and rapid heating by microwave irradiation in combination with sealed vessel
processing in many cases enables reactions to be carried out in a fraction of the time …

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

D Garella, E Borretto, A Di Stilo, K Martina… - …, 2013 - pubs.rsc.org
The syntheses of almost all N-heterocycles have now been successfully performed under
microwave irradiation and have provided significant improvements in the reaction time and …

Selective N-monoalkylation of aromatic amines with benzylic alcohols by a hydrogen autotransfer process catalyzed by unmodified magnetite

R Martínez, DJ Ramón, M Yus - Organic & biomolecular chemistry, 2009 - pubs.rsc.org
A new catalyst for an old material: magnetite is a good catalyst for the selective N-alkylation
of aromatic amines using benzylic alcohols as electrophiles. The process could be repeated …

2-Aminoimidazoles from Leucetta Sponges: Synthesis and biology of an important pharmacophore

JD Sullivan, RL Giles, RE Looper - Current Bioactive …, 2009 - ingentaconnect.com
This review will focus on the ability of the 2-aminoimidazole to occupy a unique subset of
chemical space which makes it an ideal pharmacophore for the development of small …

α-Haloaldehydes: versatile building blocks for natural product synthesis

R Britton, B Kang - Natural Product Reports, 2013 - pubs.rsc.org
Covering: up to July 2012 The diastereoselective addition of organometallic reagents to α-
chloroaldehydes was first reported in 1959 and occupies a historically significant role as the …

Structure− Activity Relationship of 4 (5)-Aryl-2-amino-1 H-imidazoles, N 1-Substituted 2-Aminoimidazoles and Imidazo [1, 2-a] pyrimidinium Salts as Inhibitors of …

HPL Steenackers, DS Ermolat'ev… - Journal of medicinal …, 2011 - ACS Publications
A library of 112 4 (5)-aryl-2-amino-1 H-imidazoles, 4, 5-diphenyl-2-amino-1 H-imidazoles,
and N 1-substituted 4 (5)-phenyl-2-aminoimidazoles was synthesized and tested for the …

Hit-to-lead optimization of novel phenyl imidazole carboxamides that are active against Leishmania donovani

N McNamara, E Saunders, S Varghese… - European Journal of …, 2022 - Elsevier
Visceral leishmaniasis is a potentially fatal disease caused by the parasitic protists,
Leishmania donovani and L. infantum. Current treatments remain unsuitable due to cost, the …

Elements as Direct Feedstocks for Organic Synthesis: Fe/I2/O2 for Diamination of 2-Cyclohexenones with 2-Aminopyrimidine and 2-Aminopyridines

TB Nguyen, M Corbin, P Retailleau, L Ermolenko… - Organic …, 2015 - ACS Publications
Elements as feedstocks for organic synthesis, the trio of metallic iron, molecular iodine, and
dioxygen, were found to be an excellent tool for oxidative regioselective diamination of …

Synthetic approaches and functionalizations of imidazo [1, 2-a] pyrimidines: an overview of the decade

R Goel, V Luxami, K Paul - RSC advances, 2015 - pubs.rsc.org
Imidazo [1, 2-a] pyrimidine has been receiving significant attention in the synthetic chemistry
community through different chemosynthetic methodologies viz., multicomponent reactions …

A divergent synthesis of substituted 2-aminoimidazoles from 2-aminopyrimidines

DS Ermolat'ev, EV Van der Eycken - The Journal of Organic …, 2008 - ACS Publications
A new divergent and efficient synthesis of substituted 2-aminoimidazoles 5 and 6 has been
developed starting from the readily available 2-aminopyrimidines 1 and α-bromocarbonyl …