Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

The molecular signatures of epigenetic regulation and chromatin architectures are
fundamental to genetically determined biological processes. Covalent and post-translational …

Upon prolonged endoplasmic reticulum (ER) stress, cells attenuate protein translation to
prevent accumulation of unfolded proteins. Here we show that Sestrin2 is critical for this …

The clock protein BMAL1 (brain and muscle Arnt-like protein 1) participates in circadian
regulation of lipid metabolism, but its contribution to insulin AKT-regulated hepatic lipid …

Regulatory T (Treg) cells are a CD4 T-cell subset with an important role in immune
tolerance; however, the mechanisms underlying Treg cell differentiation and function are …

Fibroblast growth factor (FGF) 21 is one of the FGF members with special endocrine
properties. In the last twenty years, it has attracted intense research and development for its …

Iron homeostasis is critical to mammals, and dysregulation in iron homeostasis usually leads
to severe disorders including various cancers. Massive hepcidin secretion is an indicator of …

FGF21 is a potent metabolic regulator of energy balance, body composition, lipid
metabolism, and glucose homeostasis. Initial studies reported that it was increased by …

Given the increasing prevalence of obesity and the metabolic syndrome, identification of
intrinsic molecular programs responsible for ensuring fuel homeostasis and preventing …

Immune cells develop endotoxin tolerance (ET) after prolonged stimulation. ET increases
the level of a repression mark H3K9me2 in the transcriptionally silent chromatin specifically …