Complement system part I–molecular mechanisms of activation and regulation
NS Merle, SE Church, V Fremeaux-Bacchi… - Frontiers in …, 2015 - frontiersin.org
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …
against pathogens and in host homeostasis. The complement system is initiated by …
Complement activation, regulation, and molecular basis for complement‐related diseases
The complement system is an essential element of the innate immune response that
becomes activated upon recognition of molecular patterns associated with microorganisms …
becomes activated upon recognition of molecular patterns associated with microorganisms …
Atypical aHUS: state of the art
CM Nester, T Barbour, SR de Cordoba… - Molecular …, 2015 - Elsevier
Tremendous advances in our understanding of the thrombotic microangiopathies (TMAs)
have revealed distinct disease mechanisms within this heterogeneous group of diseases. As …
have revealed distinct disease mechanisms within this heterogeneous group of diseases. As …
[HTML][HTML] Atypical hemolytic uremic syndrome
D Kavanagh, TH Goodship, A Richards - Seminars in nephrology, 2013 - Elsevier
Hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia,
thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease …
thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease …
Complement control protein factor H: the good, the bad, and the inadequate
VP Ferreira, MK Pangburn, C Cortés - Molecular immunology, 2010 - Elsevier
The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …
participates in elimination of pathogens and altered host cells and comprises an essential …
Protection of host cells by complement regulators
CQ Schmidt, JD Lambris, D Ricklin - Immunological reviews, 2016 - Wiley Online Library
The complement cascade is an ancient immune‐surveillance system that not only provides
protection from pathogen invasion but has also evolved to participate in physiological …
protection from pathogen invasion but has also evolved to participate in physiological …
Statistical validation of rare complement variants provides insights into the molecular basis of atypical hemolytic uremic syndrome and C3 glomerulopathy
Atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) are associated
with dysregulation and overactivation of the complement alternative pathway. Typically …
with dysregulation and overactivation of the complement alternative pathway. Typically …
Complement factor H in host defense and immune evasion
Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …
pathogen-and damage-associated molecular patterns, and initiates the immune response in …
Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical …
I Moore, L Strain, I Pappworth… - Blood, The Journal …, 2010 - ashpublications.org
Factor H autoantibodies have been reported in approximately 10% of patients with atypical
hemolytic uremic syndrome (aHUS) and are associated with deficiency of factor H–related …
hemolytic uremic syndrome (aHUS) and are associated with deficiency of factor H–related …
Structure of complement fragment C3b–factor H and implications for host protection by complement regulators
Factor H (FH) is an abundant regulator of complement activation and protects host cells from
self-attack by complement. Here we provide insight into the regulatory activity of FH by …
self-attack by complement. Here we provide insight into the regulatory activity of FH by …