The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …

Abstract Disruption of Akt and Erk-mediated signal transduction significantly contributes in
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …

The risk of cancer and associated mortality increases substantially in humans from the age
of 65 years onwards,,,,–. Nonetheless, our understanding of the complex relationship …

The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …

Invasion, metastasis and therapy resistance are the major cause of cancer‐associated
deaths, and the EMT‐inducing transcription factor ZEB 1 is a crucial stimulator of these …

Aberrant expression of embryonic epithelial-mesenchymal transition-inducing transcription
factors (EMT-TFs) in epithelial cells triggers EMT, neoplastic transformation, stemness, and …

Transdifferentiation of epithelial cells into cells with mesenchymal properties and
appearance, that is, epithelial–mesenchymal transition (EMT), is essential during …

Cancer is a complex multistep process involving genetic and epigenetic changes that
eventually result in the activation of oncogenic pathways and/or inactivation of tumor …

The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is a central signaling
pathway that regulates a wide variety of stimulated cellular processes, including mainly …