The role of IL-6 in cancer cell invasiveness and metastasis—overview and therapeutic opportunities

M Rašková, L Lacina, Z Kejík, A Venhauerová… - Cells, 2022 - mdpi.com
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various
homeostatic and pathological processes. These activities range from regulating embryonic …

[HTML][HTML] Breast cancer: molecular mechanisms of underlying resistance and therapeutic approaches

M Tufail, J Cui, C Wu - American journal of cancer research, 2022 - ncbi.nlm.nih.gov
Breast cancer (BC) affects over 250,000 women in the US each year. Drug-resistant cancer
cells are responsible for most breast cancer fatalities. Scientists are developing novel …

TGFβ-directed therapeutics: 2020

BA Teicher - Pharmacology & therapeutics, 2021 - Elsevier
The transforming growth factor-beta (TGFβ) pathway is essential during embryo
development and in maintaining normal homeostasis. During malignancy, the TGFβ …

Hepatitis B viral protein HBx and the molecular mechanisms modulating the hallmarks of hepatocellular carcinoma: a comprehensive review

E Sivasudhan, N Blake, Z Lu, J Meng, R Rong - Cells, 2022 - mdpi.com
With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the
most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X …

MiRNA-related metastasis in oral cancer: moving and shaking

M Eslami, S Khazeni, XM Khanaghah, MH Asadi… - Cancer cell …, 2023 - Springer
Across the world, oral cancer is a prevalent tumor. Over the years, both its mortality and
incidence have grown. Oral cancer metastasis is a complex process involving cell invasion …

Antitumor drugs and their targets

Z Dembic - Molecules, 2020 - mdpi.com
Through novel methodologies, including both basic and clinical research, progress has
been made in the therapy of solid cancer. Recent innovations in anticancer therapies …

Real-time detection of circulating tumor cells in bloodstream using plasmonic fiber sensors

S Zhu, Z Xie, Y Chen, S Liu, YW Kwan, S Zeng, W Yuan… - Biosensors, 2022 - mdpi.com
Circulating tumor cells (CTCs) are single cancer cells or cancer cell clusters that are present
in the circulatory system. Assessing CTC levels in patients can aid in the early detection of …

The biological roles and molecular mechanisms of long non-coding RNA MEG3 in the hallmarks of cancer

L Zhang, F Zhao, W Li, G Song, V Kasim, S Wu - Cancers, 2022 - mdpi.com
Simple Summary MEG3 is a class of lncRNA, which is considered a tumor suppressor. It is
lost or decreased in different biological processes of various human tumors and is closely …

Natural isoflavonoids in invasive cancer therapy: From bench to bedside

L Cayetano‐Salazar, M Olea‐Flores… - Phytotherapy …, 2021 - Wiley Online Library
Cancer is a public health problem worldwide, and one of the crucial steps within tumor
progression is the invasion and metastasis of cancer cells, which are directly related to …

A genetically encoded magnetic resonance imaging reporter enables sensitive detection and tracking of spontaneous metastases in deep tissues

NN Nyström, SW McRae, FM Martinez, JJ Kelly… - Cancer Research, 2023 - AACR
Metastasis is the leading cause of cancer-related death. However, it remains a poorly
understood aspect of cancer biology, and most preclinical cancer studies do not examine …