Piano stool Ru (II)-arene complexes having three monodentate legs: A comprehensive review on their development as anticancer therapeutics over the past decade

S Swaminathan, J Haribabu, N Balakrishnan… - Coordination chemistry …, 2022 - Elsevier
The popularity of RAPTA-C in in vivo studies has steered the way for complexes of the type
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …

Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

WDJ Tremlett, DM Goodman, TR Steel, S Kumar… - Coordination chemistry …, 2021 - Elsevier
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

Ru(II)-p-Cymene Complexes of Furoylthiourea Ligands for Anticancer Applications against Breast Cancer Cells

DP Dorairaj, J Haribabu, M Dharmasivam… - Inorganic …, 2023 - ACS Publications
Half-sandwich Ru (II) complexes containing nitro-substituted furoylthiourea ligands, bearing
the general formula [(η 6-p-cymene) RuCl2 (L)](1–6) and [(η 6-p-cymene) RuCl …

Impact of aliphatic acyl and aromatic thioamide substituents on the anticancer activity of Ru (ii)-p-cymene complexes with acylthiourea ligands—in vitro and in vivo …

S Swaminathan, J Haribabu, MKM Subarkhan… - Dalton …, 2021 - pubs.rsc.org
Six different acylthiourea ligands (L1–L6) and their corresponding Ru (II)-p-cymene
complexes (P1–P6) were designed to explore the structure–activity relationship of the …

New organoruthenium (II) complexes containing N, X-donor (X= O, S) heterocyclic chelators: synthesis, spectral characterization, in vitro cytotoxicity and apoptosis …

G Kalaiarasi, MM Subarkhan, CKF Safwana… - Inorganica chimica …, 2022 - Elsevier
Four Schiff base ligands namely ((1E)-1-(1-(6-chloro-2-oxo-2H-chromen-3-yl) ethylidene)
semicarbazide)(HL 1),((1E)-1-(1-(6-chloro-2-oxo-2H-chromen-3-yl) ethylidene …

Coordination behavior of acylthiourea ligands in their Ru (II)–benzene complexes─ structures and anticancer activity

S Swaminathan, J Haribabu… - …, 2022 - ACS Publications
Acylthiourea ligands have applications in both synthetic and applied chemistry. The skeleton
of the ligand contains several heteroatoms which offer variable coordination modes in their …

Various coordination modes of new coumarin Schiff bases toward Cobalt (III) ion: synthesis, spectral characterization, in vitro cytotoxic activity, and investigation of …

K Giriraj, MS Mohamed Kasim… - Applied …, 2022 - Wiley Online Library
Four Co (III) complexes containing substituted acetyl coumarin Schiff bases have been
synthesized and structurally characterized using IR, UV–visible, 1H nuclear magnetic …

Monodentately-coordinated bioactive moieties in multimodal half-sandwich organoruthenium anticancer agents

TR Steel, F Walsh, A Wieczorek-Błauż, M Hanif… - Coordination chemistry …, 2021 - Elsevier
Metallodrugs have a central role in the treatment and diagnosis of diseases. To overcome
potential toxicity and equip metal-based anticancer agents with biological activity, the choice …

An overview on the anticancer activity of Ru (II)/acylthiourea complexes

GH Ribeiro, AR Costa, AR de Souza… - Coordination Chemistry …, 2023 - Elsevier
This review outlines research on the development of ruthenium complexes containing
acylthiourea ligands with potential antitumor activity, which have been leveraged in recent …

Hinged Bipodal Furoylthiourea-Based Ru(II)-Arene Complexes: Effect of (ortho, meta, or para)-Substitution on Coordination and Anticancer Activity

S Swaminathan, J Haribabu, M Dharmasivam… - Inorganic …, 2023 - ACS Publications
We set out to design and synthesize bipodal ligands with the phenyl group as the spacer
and varied the substitution on the spacer between ortho (L1), meta (L2), and para (L3). The …