Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

▪ Abstract This review describes the three mammalian glutathione transferase (GST)
families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated …

Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de
novo and salvage synthesis serves to maintain a reduced cellular environment and the …

Glutathione transferases (GSTs) are a diverse family of enzymes found ubiquitously in
aerobic organisms. They play a central role in the detoxification of both endogenous and …

The unique anatomical features of turtles have raised unanswered questions about the
origin of their unique body plan. We generated and analyzed draft genomes of the soft-shell …

In the last decade the tumultuous development of “omics” greatly improved our ability to
understand protein structure, function and evolution, and to define their roles and networks …

▪ Abstract Pseudogenes have been defined as nonfunctional sequences of genomic DNA
originally derived from functional genes. It is therefore assumed that all pseudogene …

Antioxidant enzymes perform a variety of vital functions including the reduction of life‐
shortening oxidative damage. We used the honey bee genome sequence to identify the …

Drosophila melanogaster glutathione S‐transferase DmGSTS1‐1 (earlier designated as
GST‐2) is related to sigma class GSTs and was previously described as an indirect flight …

Previous studies demonstrated that the Caenorhabditis elegans GST-p24 is upregulated at
the steady state mRNA level in response to oxidative stress [1]. A transcriptional …