Despite a prevalence greater than cancer or diabetes, there are no currently approved drugs
for the treatment of hearing loss. Research over the past two decades has led to a vastly …

To the Editor—Biologists are important stakeholders in genomic data, both as data
generators and as users of genomic data resources. Tools to efficiently visualize and …

Abstract The Hippo/Yes-associated protein (YAP) signaling pathway has been shown to be
able to maintain organ size and homeostasis by regulating cell proliferation, differentiation …

Introduction Sensorineural hearing loss results in irreversible loss of inner ear hair cells and
spiral ganglion neurons. Reduced sound detection and speech discrimination can span all …

Mammalian sensory hair cells (HCs) have limited capacity for regeneration, which leads to
permanent hearing loss after HC death. Here, we used in vitro RNA-sequencing to show that …

The loss of inner ear hair cells causes permanent hearing and balance deficits in humans
and other mammals, but non-mammals recover after supporting cells (SCs) divide and …

The sensory epithelia of the auditory and vestibular systems of vertebrates have shared
developmental and evolutionary histories. However, while the auditory epithelia show great …

To understand the changes in gene regulation and expression of MicroRNA (miRNA)
involved in external mouseear embryonic development after point mutation of the Bmp5 …

To understand the role of long noncoding RNA (lncRNA) gene regulation and changes in
expression in mouse external ear embryonic development, a BMP5 short ear mouse model …

Hundreds of millions of people worldwide have disabling hearing loss or imbalance. A major
cause of these impairments is sensory hair cell loss from loud sounds, ototoxic drugs, and …