Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Cubane: 50 years later
The fascination with elaborate molecular architectures that differ significantly from those
ordinarily present in nature have motivated synthetic, physical organic, and theoretical …
ordinarily present in nature have motivated synthetic, physical organic, and theoretical …
Cubanes in medicinal chemistry
TA Reekie, CM Williams, LM Rendina… - Journal of medicinal …, 2018 - ACS Publications
Cubane is a highly strained saturated hydrocarbon system that has historically been of
interest in theoretical organic chemistry. More recently it has become a molecule of interest …
interest in theoretical organic chemistry. More recently it has become a molecule of interest …
Mechanochemistry of cubane
We report the mechanochemical reactivity of the highly strained pentacyclic hydrocarbon
cubane. The mechanical reactivity of cubane is explored for three regioisomers with 1, 2-, 1 …
cubane. The mechanical reactivity of cubane is explored for three regioisomers with 1, 2-, 1 …
A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists
W Liu, X Jiang, Y Zu, Y Yang, Y Liu, X Sun, Z Xu… - European journal of …, 2020 - Elsevier
Abstract l-glutamate is an excitatory neurotransmitter in the central nervous system (CNS),
which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N …
which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N …
Triple-Dearomative Photocycloaddition: A Strategy to Construct Caged Molecular Frameworks
An unprecedented caged 2H-benzo-dioxo-pentacycloundecane framework was
serendipitously obtained in a single transformation via triple-dearomative …
serendipitously obtained in a single transformation via triple-dearomative …
Unlocking therapeutic potential: the role of adamantane in drug discovery
C Dane, GA Cumbers, B Allen… - Australian Journal of …, 2024 - CSIRO Publishing
The unique structural and physicochemical properties of adamantane and its derivatives
have attracted considerable attention in the field of medicinal chemistry. Substituting phenyl …
have attracted considerable attention in the field of medicinal chemistry. Substituting phenyl …
Calcium Modulating Effect of Polycyclic Cages: A Suitable Therapeutic Approach Against Excitotoxic-Induced Neurodegeneration
Neurodegenerative disorders pose a significant challenge to global healthcare systems due
to their progressive nature and the resulting loss of neuronal cells and functions …
to their progressive nature and the resulting loss of neuronal cells and functions …
Ring-Closing Metathesis Approach to Cage Propellanes Containing Oxepane and Tetrahydrofuran Hybrid System
S Kotha, SR Cheekatla, DS Mhatre - Synthesis, 2017 - thieme-connect.com
The preparation of a variety of structurally interesting oxygenated cage compounds involving
atom-economic processes such as Claisen rearrangement, Diels–Alder reaction,[2+ 2] …
atom-economic processes such as Claisen rearrangement, Diels–Alder reaction,[2+ 2] …
Ecdysterones from Rhaponticum carthamoides (Willd.) Iljin reduce hippocampal excitotoxic cell loss and upregulate mTOR signaling in rats
J Wu, L Gao, L Shang, G Wang, N Wei, T Chu, S Chen… - Fitoterapia, 2017 - Elsevier
Glutamate-induced excitotoxicity is a key pathological mechanism in many neurological
disease states. Ecdysterones derived from Rhaponticum carthamoides (Willd.) Iljin (RCI) …
disease states. Ecdysterones derived from Rhaponticum carthamoides (Willd.) Iljin (RCI) …