Simple Summary We provide an extensive review of the fundamental principles of statistical
science that are needed to accurately interpret randomized controlled trials (RCTs). We use …

The COSMIC-313 phase 3 randomized controlled trial tested the triplet combination of
cabozantinib with nivolumab and ipilimumab in comparison with nivolumab plus ipilimumab …

Introduction Hyperthermia (HT) induces various cellular biological processes, such as repair
impairment and direct HT cell killing. In this context, in-silico biophysical models that …

In the recent years, a growing number of approved regimens have firmly established check
point inhibitors (CPI) as the treatment backbone for metastatic clear cell renal cell carcinoma …

This paper proposes an original approach for modelling medical expertise and simulating
medical strategies. A knowledge-based system is used to model therapeutic strategies …