Abstract Studies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the
African trypanosome, Trypanosoma brucei, have yielded a remarkable range of novel and …

VSG stands for variant surface glycoprotein, the major surface component of the protozoan
parasite Trypanosoma brucei while it exists in the blood and tissues of its mammalian host …

Trypanosoma brucei evades the adaptive immune response through the expression of
antigenically distinct Variant Surface Glycoprotein (VSG) coats. To understand the …

Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …

Survival of the African trypanosome within its mammalian hosts, and hence transmission
between hosts, relies upon antigenic variation, where stochastic changes in the composition …

Antigenic variation in African trypanosomes requires monoallelic transcription and switching
of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by '70 bp' …

Trypanosoma brucei causes human African trypanosomiasis and regularly switches its
major surface antigen, VSG, thereby evading the host's immune response. VSGs are …

Trypanosoma brucei is a protozoan parasite that lacks many transcription factors found in
other eukaryotes, such as those whose binding demarcates enhancers. T. brucei retains …

For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the
most deleterious types of DNA lesions. DSB processing and repair can cause sequence …

RNA–DNA hybrids are epigenetic features of all genomes that intersect with many
processes, including transcription, telomere homeostasis, and centromere function …