Target protein degradation by protacs: A budding cancer treatment strategy

D Choudhary, A Kaur, P Singh, G Chaudhary… - Pharmacology & …, 2023 - Elsevier
Cancer is one of the most common causes of death. So, its lethal effect increases with time.
Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or …

Transcriptional stress memory and transgenerational inheritance of drought tolerance in plants

NH Nguyen, NT Vu, JJ Cheong - International Journal of Molecular …, 2022 - mdpi.com
Plants respond to drought stress by producing abscisic acid, a chemical messenger that
regulates gene expression and thereby expedites various physiological and cellular …

[HTML][HTML] The Polycomb repressive complex 2 deposits H3K27me3 and represses transposable elements in a broad range of eukaryotes

T Hisanaga, F Romani, S Wu, T Kowar, Y Wu… - Current Biology, 2023 - cell.com
The mobility of transposable elements (TEs) contributes to evolution of genomes. Their
uncontrolled activity causes genomic instability; therefore, expression of TEs is silenced by …

The importance of networking: plant polycomb repressive complex 2 and its interactors

J Godwin, S Farrona - Epigenomes, 2022 - mdpi.com
Polycomb Repressive Complex 2 (PRC2) is arguably the best-known plant complex of the
Polycomb Group (PcG) pathway, formed by a group of proteins that epigenetically represses …

Post-Translational Modifications in Histones and Their Role in Abiotic Stress Tolerance in Plants

M Sharma, AK Sidhu, MK Samota, M Gupta, P Koli… - Proteomes, 2023 - mdpi.com
Abiotic stresses profoundly alter plant growth and development, resulting in yield losses.
Plants have evolved adaptive mechanisms to combat these challenges, triggering intricate …

[HTML][HTML] Dynamics of polycomb group marks in Arabidopsis

F Baile, M Calonje - Current Opinion in Plant Biology, 2024 - Elsevier
Abstract Polycomb Group (PcG) histone-modifying system is key in maintaining gene
repression, providing a mitotically heritable cellular memory. Nevertheless, to allow plants to …

Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core

A Sharaf, M Vijayanathan, M Oborník… - Life Science …, 2022 - life-science-alliance.org
Polycomb repressive complex 2 (PRC2) is involved in maintaining transcriptionally silent
chromatin states through methylating lysine 27 of histone H3 by the catalytic subunit …

Molecular Mimicry of Transposable Elements in Plants

J Chu, J Newman, J Cho - Plant and Cell Physiology, 2024 - academic.oup.com
Transposable elements (TEs) are mobile DNA elements that are particularly abundant in the
plant genomes. They have long been considered as junk DNA; however, a growing body of …

Arabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulations

Y Yu, S Wang, Z Wang, R Gao, J Lee - Epigenetics, 2023 - Taylor & Francis
Histones are subjected to extensive covalent modifications that affect inter-nucleosomal
interactions as well as alter chromatin structure and DNA accessibility. Through switching …

Research advances of polycomb group proteins in regulating mammalian development

Y Li, Y Mo, C Chen, J He, Z Guo - Frontiers in Cell and …, 2024 - frontiersin.org
Polycomb group (PcG) proteins are a subset of epigenetic factors that are highly conserved
throughout evolution. In mammals, PcG proteins can be classified into two muti-proteins …