Cell biology and immunology of malaria
JC Hafalla, O Silvie, K Matuschewski - Immunological reviews, 2011 - Wiley Online Library
Malaria is a vector‐borne infectious disease caused by unicellular parasites of the genus
Plasmodium. These obligate intracellular parasites have the unique capacity to infect and …
Plasmodium. These obligate intracellular parasites have the unique capacity to infect and …
Immune effector mechanisms in malaria
Malaria, a disease responsible for immense human suffering, is caused by infection with
Plasmodium spp. parasites, which have a very complex life cycle ntigenically unique stages …
Plasmodium spp. parasites, which have a very complex life cycle ntigenically unique stages …
Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection
Viral infections induce extensive T cell proliferation in vivo, but the specificity of the majority
of the responding T cells has not been defined. To address this issue we used tetramers of …
of the responding T cells has not been defined. To address this issue we used tetramers of …
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells
The rules that govern memory T cell differentiation are not well understood. This study
shows that after antigenic stimulation naïve CD8+ T cells become committed to dividing at …
shows that after antigenic stimulation naïve CD8+ T cells become committed to dividing at …
4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses
JT Tan, JK Whitmire, R Ahmed, TC Pearson… - The Journal of …, 1999 - journals.aai.org
1BB (CD137) is a costimulatory molecule expressed on activated T cells and interacts with 4-
1BB ligand (4-1BBL) on APCs. To investigate the role of 4-1BB costimulation for the …
1BB ligand (4-1BBL) on APCs. To investigate the role of 4-1BB costimulation for the …
A decade after the generation of a negative-sense RNA virus from cloned cDNA–what have we learned?
Since the first generation of a negative-sense RNA virus entirely from cloned cDNA in 1994,
similar reverse genetics systems have been established for members of most genera of the …
similar reverse genetics systems have been established for members of most genera of the …
Phase I study of a vaccine using recombinant vaccinia virus expressing PSA (rV‐PSA) in patients with metastatic androgen‐independent prostate cancer
Abstract BACKGROUND A Phase I trial of recombinant vaccinia prostate specific antigen (rV‐
PSA) in patients with advanced metastatic prostate cancer was conducted. This report …
PSA) in patients with advanced metastatic prostate cancer was conducted. This report …
Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime–boost …
SC Gilbert, J Schneider, CM Hannan, JT Hu… - Vaccine, 2002 - Elsevier
Recombinant replication-defective adenovirus expressing the CS gene from Plasmodium
berghei (Ad-PbCS) was found to induce a strong CD8+ T cell response after intra-dermal or …
berghei (Ad-PbCS) was found to induce a strong CD8+ T cell response after intra-dermal or …
The induction of virus-specific CTL as a function of increasing epitope expression: responses rise steadily until excessively high levels of epitope are attained
EJ Wherry, KA Puorro, A Porgador… - The Journal of …, 1999 - journals.aai.org
The role of epitope expression levels in CD8+ T cell priming has been controversial. Yet this
parameter is of great importance in the design of rational approaches to optimize CTL …
parameter is of great importance in the design of rational approaches to optimize CTL …
Induction of CD8+ T cells using heterologous prime‐boost immunisation strategies
J Schneider, SC Gilbert, CM Hannan… - Immunological …, 1999 - Wiley Online Library
One of the current challenges in vaccine design is the development of antigen delivery
systems or vaccination strategies that induce higb protective levels of CD8+ T cells. These …
systems or vaccination strategies that induce higb protective levels of CD8+ T cells. These …