Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …

Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …

The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

A neuroimmune crosstalk is involved in somatic and visceral pathological pain including
inflammatory and neuropathic components. Apart from microglia essential for spinal and …

SARS-CoV-2 is a novel coronavirus that infects cells through the angiotensin-converting
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …

Musculoskeletal pain is a condition that characterises several diseases and represents a
constantly growing issue with enormous socio-economic burdens, highlighting the …

Neuroinflammation is a crucial mechanism in many neurological disorders. Injury to the
peripheral sensory nerves leads to a neuroinflammatory response in the somatosensory …

Stem cells have emerged as a potential therapy for a range of neural insults, but their
application in Alzheimer's disease (AD) is still limited and the mechanisms underlying the …

Pain is a fundamental feature of inflammation. The immune system plays a critical role in the
activation of sensory neurons and there is increasing evidence of neuro-inflammatory …

Knowledge about the mechanisms of transmission and the processing of nociceptive
information, both in healthy and pathological states, has greatly expanded in recent years …