Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …

Current first-line treatment of patients with high-grade serous ovarian cancer (HGSOC)
involves the use of cytotoxic drugs that frequently lead to recurrent tumors exhibiting …

Single-cell RNA-seq (scRNAseq) is a powerful tool to study heterogeneity of cells. Recently,
several clustering based methods have been proposed to identify distinct cell populations …

Radial glia (RG) cells are the first neural stem cells to appear during embryonic
development. Adult human glioblastomas harbor a subpopulation of RG-like cells with …

During human evolution, major changes in our societal conditions and environment took
place without sufficient time for concomitant genetic alterations, leading to out of step …

The gonads are unique among the body's organs in having a developmental choice: testis
or ovary formation. Gonadal sex differentiation involves common progenitor cells that form …

The organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) is an endocrine-
disrupting compound (EDC) that has been banned by most countries for decades. However …

Immune transcripts are essential for depicting onco-immunologic interactions. However,
whether cancer cells mimic immune transcripts to reprogram onco-immunologic interaction …

Multiple studies using single-cell RNA sequencing (scRNAseq) have failed to detect stem
cells in adult ovaries. We have maintained that two populations of ovarian stem cells …

In the last 15 years, single-cell technologies have become robust and indispensable tools to
investigate cell heterogeneity. Beyond transcriptomic, genomic and epigenome analyses …