The recent increase in genomic data is revealing an unexpected perspective of gene loss as
a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This …

Microbial experimental evolution uses controlled laboratory populations to study the
mechanisms of evolution. The molecular analysis of evolved populations enables empirical …

RNA editing in various organisms commonly restores RNA sequences to their ancestral
state, but its adaptive advantages are debated. In fungi, restorative editing corrects …

The economy of protein production is central to cell physiology, being intimately linked with
cell division rate and cell size. Attempts to model cellular physiology are limited by the …

Epistatic interactions between mutations can make evolutionary trajectories contingent on
the chance occurrence of initial mutations. We used experimental evolution in …

Experimental techniques that survey an entire genome demand flexible, highly interactive
visualization tools that can display new data alongside foundation datasets, such as …

The main focus in development of yeast cell factories has generally been on establishing
optimal activity of heterologous pathways and further metabolic engineering of the host …

The dramatic phenotypic changes that occur in organisms during domestication leave
indelible imprints on their genomes. Although many domesticated plants and animals have …

Quantitative empirical relationships between cell composition and growth rate played an
important role in the early days of microbiology. Gradually, the focus of the field began to …

In most conditions, glucose is the best carbon source for E. coli: it provides faster growth
than other sugars and is consumed first in sugar mixtures. Here we identify conditions in …