Alternative tumour-specific antigens
The study of tumour-specific antigens (TSAs) as targets for antitumour therapies has
accelerated within the past decade. The most commonly studied class of TSAs are those …
accelerated within the past decade. The most commonly studied class of TSAs are those …
Neoantigens: promising targets for cancer therapy
Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
Therapeutic cancer vaccines: advancements, challenges, and prospects
T Fan, M Zhang, J Yang, Z Zhu, W Cao… - Signal Transduction and …, 2023 - nature.com
With the development and regulatory approval of immune checkpoint inhibitors and adoptive
cell therapies, cancer immunotherapy has undergone a profound transformation over the …
cell therapies, cancer immunotherapy has undergone a profound transformation over the …
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence
Y Xu, GH Su, D Ma, Y Xiao, ZM Shao… - Signal Transduction and …, 2021 - nature.com
Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …
Best practices for bioinformatic characterization of neoantigens for clinical utility
Neoantigens are newly formed peptides created from somatic mutations that are capable of
inducing tumor-specific T cell recognition. Recently, researchers and clinicians have …
inducing tumor-specific T cell recognition. Recently, researchers and clinicians have …
Current understanding of an emerging role of HLA-DRB1 gene in rheumatoid arthritis–from research to clinical practice
Rheumatoid arthritis (RA) is an autoimmune disease with an unclear pathogenic
mechanism. However, it has been proven that the key underlying risk factor is a genetic …
mechanism. However, it has been proven that the key underlying risk factor is a genetic …
Applying next-generation sequencing platforms for pharmacogenomic testing in clinical practice
Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy.
Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical …
Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical …
Bioinformatics strategies, challenges, and opportunities for next generation sequencing-based HLA genotyping
S Klasberg, V Surendranath, V Lange… - Transfusion Medicine …, 2019 - karger.com
The advent of next generation sequencing (NGS) has altered the face of genotyping the
human leukocyte antigen (HLA) system in clinical, stem cell donor registry, and research …
human leukocyte antigen (HLA) system in clinical, stem cell donor registry, and research …
Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data
A Claeys, P Merseburger, J Staut, K Marchal… - BMC genomics, 2023 - Springer
Abstract Background The Human Leukocyte Antigen (HLA) genes are a group of highly
polymorphic genes that are located in the Major Histocompatibility Complex (MHC) region …
polymorphic genes that are located in the Major Histocompatibility Complex (MHC) region …