Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation,
progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and …

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …

Adipose tissue plays a central role in regulating whole-body energy and glucose
homeostasis through its subtle functions at both organ and systemic levels. On one hand …

Obesity is an energy‐rich condition associated with overnutrition, which impairs systemic
metabolic homeostasis and elicits stress. It also activates an inflammatory process in …

Obesity and its comorbidities are closely related to the inflammatory environment created by
expanded adipose tissue. Several mechanisms trigger inflammation in adipose tissue …

Obesity as an independent risk factor for cardiovascular diseases (CVDs) leads to an
increase in morbidity, mortality, and a shortening of life span. The changes in heart structure …

Obesity is a problem of epidemic proportions in many developed nations. Increased body
mass index and obesity are associated with a significantly worse outcome for many cancers …

Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases
(NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β …

Unhealthy dietary patterns-induced obesity and obesity-related complications pose a great
threat to human health all over the world. Accumulating evidence suggests that the …