Immunogenic cell death inducing metal complexes for cancer therapy

L Zhang, N Montesdeoca, J Karges… - Angewandte Chemie …, 2023 - Wiley Online Library
Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that
metastases and tumor relapse are the leading causes of cancer‐associated deaths. While …

Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future

S Sen, M Won, MS Levine, Y Noh… - Chemical Society …, 2022 - pubs.rsc.org
Cancer is the deadliest disease in the world behind heart disease. Sadly, this remains true
even as we suffer the ravages of the Covid-19 pandemic. Whilst current chemo-and …

Recent advances in the synthesis, stability, and activation of platinum (IV) anticancer prodrugs

Z Xu, Z Wang, Z Deng, G Zhu - Coordination Chemistry Reviews, 2021 - Elsevier
Platinum-based anticancer drugs have been widely applied in clinical settings for more than
40 years. The remarkable breakthroughs that have come from the use of these complexes in …

Target profiling of an iridium (III)-based immunogenic cell death inducer unveils the engagement of unfolded protein response regulator BiP

X Xiong, KB Huang, Y Wang, B Cao… - Journal of the …, 2022 - ACS Publications
Clinical chemotherapeutic drugs have occasionally been observed to induce antitumor
immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic …

Recent Progress in Photodynamic Immunotherapy with Metal‐Based Photosensitizers

K Xiong, F Wei, Y Chen, L Ji, H Chao - Small Methods, 2023 - Wiley Online Library
Cancer ranks as a leading cause of death. There is an urgent need to develop minimally
invasive methods to eradicate tumors and prevent their recurrence. As a light‐driven …

Potent Zinc(II)-Based Immunogenic Cell Death Inducer Triggered by ROS-Mediated ERS and Mitochondrial Ca2+ Overload

LS Liao, Y Chen, C Hou, YH Liu, GF Su… - Journal of Medicinal …, 2023 - ACS Publications
Zn1 and Zn2 are Zn-based complexes that activate the immunogenic cell death (ICD) effect
by Ca2+-mediated endoplasmic reticulum stress (ERS) and mitochondrial dysfunction …

Platinum (IV) and platinum (II) anticancer complexes with biologically active releasable ligands

P Štarha, R Křikavová - Coordination Chemistry Reviews, 2024 - Elsevier
The concept of multi-action octahedral platinum (IV) complexes is based on the rational
derivatization of anticancer square-planar platinum (II) compounds (eg, cisplatin or …

Platinum‐Metformin Conjugates Acting as Promising PD‐L1 Inhibitors through the AMP‐Activated Protein Kinase Mediated Lysosomal Degradation Pathway

B Liu, BB Liang, WD Cao, XX Su, Q Cao… - Angewandte …, 2024 - Wiley Online Library
With the development of metalloimmunology, the potential of platinum drugs in cancer
immunotherapy has attracted extensive attention. Although immunochemotherapy …

[HTML][HTML] Induction of immunogenic cell death by novel platinum-based anticancer agents

X Chang, M Bian, L Liu, J Yang, Z Yang, Z Wang… - Pharmacological …, 2023 - Elsevier
Traditional platinum-based anticancer drugs, led by cisplatin, play an important role in
chemotherapy. However, the development of platinum compounds is limited due to serious …

Rising interest in the development of metal complexes in cancer immunotherapy

ZY Li, QH Shen, ZW Mao, CP Tan - Chemistry–An Asian …, 2022 - Wiley Online Library
Metal complexes have shown great potential in cancer immunotherapy. This review briefly
introduces the basic concepts and strategies of cancer immunotherapy and summarizes the …