A central mechanism regulating translation initiation in response to environmental stress
involves phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) …

Cells must be able to sense and adapt to their surroundings to thrive in a dynamic
environment. Key to adapting to a low nutrient environment is the Integrated Stress …

Stalling during translation triggers ribosome quality control (RQC) to maintain proteostasis.
Recently, stalling has also been linked to the activation of integrated stress response (ISR) …

Cells dynamically adjust their protein translation profile to maintain homeostasis in changing
environments. During nutrient stress, the kinase general control nonderepressible 2 (GCN2) …

The General Amino Acid Control is a conserved response to amino acid starvation involving
activation of protein kinase Gcn2, which phosphorylates eukaryotic initiation factor 2 (eIF2α) …

Diverse environmental insults induce the integrated stress response (ISR), which features
eIF2 phosphorylation and translational control that serves to restore protein homeostasis …

Protein kinase Gcn2 attenuates protein synthesis in response to amino acid starvation while
stimulating translation of a transcriptional activator of amino acid biosynthesis. Gcn2 …

Small-molecule kinase inhibitors represent a major group of cancer therapeutics, but tumor
responses are often incomplete. To identify pathways that modulate kinase inhibitor …

GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely
rewiring the metabolism of cells when they are put under amino acid starvation stress …

The development of nonalcoholic fatty liver disease (NAFLD) is associated with increased
reactive oxygen species (ROS) production. Previous observations on the contradictory roles …