Non-invasive delivery strategies for biologics

AC Anselmo, Y Gokarn, S Mitragotri - Nature Reviews Drug Discovery, 2019 - nature.com
Biologics now constitute a significant element of available medical treatments. Owing to their
clinical and commercial success, biologics are a rapidly growing class and have become a …

[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

'Green'nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases

M Zu, D Xie, BSB Canup, N Chen, Y Wang, R Sun… - Biomaterials, 2021 - Elsevier
Although synthesized nanotherapeutics (NTs) are attractive for the oral treatment of colon
diseases, their clinical translations are constrained by the unsatisfactory therapeutic …

Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

J Zhao, J Yang, Y Xie - International journal of pharmaceutics, 2019 - Elsevier
Although flavonoid compounds have various pharmacological applications, they generally
exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem …

Antimicrobial peptides–Advances in development of therapeutic applications

HX Luong, TT Thanh, TH Tran - Life sciences, 2020 - Elsevier
The severe infection is becoming a significant health problem which threaten the lives of
patients and the safety and economy of society. In the way of finding new strategy …

[HTML][HTML] Formulation, stabilisation and encapsulation of bacteriophage for phage therapy

DJ Malik, IJ Sokolov, GK Vinner, F Mancuso… - Advances in colloid and …, 2017 - Elsevier
Against a backdrop of global antibiotic resistance and increasing awareness of the
importance of the human microbiota, there has been resurgent interest in the potential use of …

Intestinal absorption study: Challenges and absorption enhancement strategies in improving oral drug delivery

M Azman, AH Sabri, QK Anjani, MF Mustaffa… - Pharmaceuticals, 2022 - mdpi.com
The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …

Bioavailability of bioactive peptides derived from food proteins across the intestinal epithelial membrane: A review

Q Xu, H Hong, J Wu, X Yan - Trends in Food Science & Technology, 2019 - Elsevier
Abstract Background Bioactive peptides (BAPs) play a crucial physiological role in human
health. To exert their biological effects after oral administration, BAPs have to be transported …

Current state and challenges in developing oral vaccines

JEV Ramirez, LA Sharpe, NA Peppas - Advanced drug delivery reviews, 2017 - Elsevier
While vaccination remains the most cost effective strategy for disease prevention,
communicable diseases persist as the second leading cause of death worldwide. There is a …

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

AA Date, J Hanes, LM Ensign - Journal of Controlled Release, 2016 - Elsevier
The oral route is a preferred method of drug administration, though achieving effective drug
delivery and minimizing off-target side effects is often challenging. Formulation into …