Angiogenesis Page 1 CHAPTER 42 Angiogenesis JUDAH FOLKMAN I. Introduction
Angiogenesis is the generation of new capillary blood vessels. While all subsequent vessels …

Often those diseases most evasive to therapeutic intervention usurp the human body's own
cellular machinery or deregulate normal physiological processes for propagation. Tumor …

Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The
nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced …

Publisher Summary The fibroblast growth factors (FGFs) constitute a family of closely related
polypeptide mitogens. There are seven members of this family, identified on the basis of …

Angiogenesis is an important process for forming new blood vessels. It is fundamental in
many biological processes including development, reproduction and wound repair. Under …

Keratinocyte growth factor (KGF) is a human mitogen that is specific for epithelial cells. The
complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast …

Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and
biochemical features of smooth muscle (SM) cells, including the presence of microfilament …

The distribution of the extracellular matrix glycoprotein, tenascin, in normal skin and healing
skin wounds in rats, has been investigated by immunohistochemistry. In normal skin …

Idiopathic pulmonary fibrosis (IPF) is a disabling disease of the lung parenchyma,
characterized by progressive accumulation of scar tissue and myofibroblast activation after …

To determine the mechanisms by which multiple forms of fibroblast growth factor (FGF)
receptors are generated, we have mapped the arrangement of exons and introns in the …