Cancer is one of the most fatal diseases of recent times that causes several deaths every
year. The disease variations in different parts of the world, the impact of available medical …

Peptides can serve as versatile cancer-targeting ligands and have been used for clinically
relevant applications such as cancer imaging and therapy. A current and long-standing …

Blockade of the interaction between programmed cell death ligand-1 (PD-L1) and its
receptor PD-1 has shown great success in cancer immunotherapy. Peptides possess unique …

Head-to-tail cyclodimerization of resin-bound oligopeptides bearing azide and alkyne
groups occurs readily by 1, 3-dipolar cycloaddition upon treatment with CuI. The process …

A series of two classes of 3-phenylpyrazolopyrimidine-1, 2, 3-triazole conjugates were
synthesized using click chemistry approach. All compounds were evaluated for inhibition of …

Submonomer synthesis of aza-peptides featuring regioselective alkylation of peptide-bound
aza-Gly residues provided ten aza-analogues of the Growth Hormone Releasing Peptide-6 …

An efficient and economical method was developed for the synthesis of 3-substituted indoles
by one-pot three-component coupling reaction of a substituted or unsubstituted …

KX2-391 (KX-01/Kinex Pharmaceuticals), N-benzyl-2-(5-(4-(2-morpholinoethoxy) phenyl)
pyridin-2-yl) acetamide, is a highly selective Src substrate binding site inhibitor. To …

Background A series of 2-amino-4-aryl-4 H-benzo [h or f] chromene-3-carbonitrile
derivatives were synthesized and evaluated for inhibition of Src kinase and cell proliferation …

Peptides are unique class of biomolecules for pharmaceutics and industries, given their
structural features that can be applied to many approaches. Although their advantages are …