Cisplatin is one of the most effective chemotherapy drugs for ovarian cancer, but resistance
is common. The initial response to platinum‑based chemotherapy is as high as 80%, but in …

Ovarian cancer is the seventh most common gynaecologic malignancy seen in women.
Majority of the patients with ovarian cancer are diagnosed at the advanced stage making …

Ovarian cancer encompasses a heterogeneous group of malignancies that involve the
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …

Ovarian cancer is the most lethal malignancy among the gynecological cancers, with a 5‐
year survival rate, mainly due to being diagnosed at advanced stages, recurrence and …

Programmed cell death (PCD) has been a major area of constantly growing interest over the
last three decades. Originally, apoptosis was considered the only mechanistic pathway for …

Despite considerable efforts to improve early detection, and advances in chemotherapy,
metastasis remains a major challenge in the clinical management of ovarian cancer. Studies …

Chemotherapy has been one of the most important treatments for advanced cancer in recent
decades. Although the sensitivity rate of initial chemotherapy is high, patients with …

Inconsistencies in the half-maximal (50%) inhibitory concentration (IC 50) data for anticancer
chemotherapeutic agents have yielded irreproducible experimental results and thus …

Oncogenic activation of the Wnt signaling pathway is common in cancers, but mutation of β‐
catenin in ovarian cancer is rare. In addition to genetic events, epigenetic modification of …

Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly
display resistance to chemotherapy, and this is the major obstacle to a better prognosis of …