Articular cartilage loss is an unmitigated risk of human spaceflight

JG Hardy - npj Microgravity, 2024 - nature.com
Microgravity and space radiation are hazards of spaceflight that have deleterious effects on
articular cartilage. Since it is not widely monitored or protected through dedicated …

Orthopedic scaffolds: evaluation of structural strength and permeability of fluid flow via an open cell neovius structure for bone tissue engineering

S Singh, SK Yadav, VK Meena, P Vashisth… - ACS Biomaterials …, 2023 - ACS Publications
The ability of bone to regenerate itself through mechanobiological responses is its dynamic
property. Mechanical cues from a neighboring environment produce the structural strain to …

Effects of short-term simulated microgravity on changes in extracellular space structure and substance diffusion and clearance

J Luo, J Yang, J Zhao, B Cui, Y Cui, S Tang, A Wang… - Acta Astronautica, 2024 - Elsevier
Substance transportation and clearance in the brain extracellular space (ECS) is crucial to
brain function, but simulated microgravity disrupts substance diffusion and clearance in the …

Bioprinting of cardiac tissue in space: where are we?

K Tabury, E Rehnberg, B Baselet… - Advanced …, 2023 - Wiley Online Library
Bioprinting in space is the next frontier in tissue engineering. In the absence of gravity, novel
opportunities arise, as well as new challenges. The cardiovascular system needs particular …

Effect of Porosity and Pore Shape on the Mechanical and Biological Properties of Additively Manufactured Bone Scaffolds

Q Liu, F Wei, M Coathup, W Shen… - Advanced Healthcare …, 2023 - Wiley Online Library
This study investigates the effect of porosity and pore shape on the biological and
mechanical behavior of additively manufactured scaffolds for bone tissue engineering (BTE) …

Sphingolipid-induced bone regulation and its emerging role in dysfunction due to disease and infection

A Seal, M Hughes, F Wei, AS Pugazhendhi… - International Journal of …, 2024 - mdpi.com
The human skeleton is a metabolically active system that is constantly regenerating via the
tightly regulated and highly coordinated processes of bone resorption and formation …

Material extrusion additive manufacturing of graphene oxide reinforced 13–93B1 bioactive glass scaffolds for bone tissue engineering applications

K Dixit, A Vishwakarma, H Kumar, K Kim, N Sinha - Additive Manufacturing, 2024 - Elsevier
Graphene-reinforced bioactive glass scaffolds have gained significant attention in the field of
bone tissue engineering due to their unique combination of mechanical strength, bioactivity …

[HTML][HTML] Cordycepin ameliorates spaceflight-induced osteoporosis by preventing BMSCs oxidative stress and senescence via interacting with PI3K p110α and …

Y Zhai, Y Zhang, K Xu, T Wang, Z Bian, L Qu… - Free Radical Biology …, 2025 - Elsevier
Spaceflight-induced osteoporosis (SFOP) is a detrimental healthcare consequence during
spaceflight. Weightlessness and ionizing radiation were main environmental factors that …

Molecular Quantum (MolQ) Communication Channel in the Gut-Brain Axis Synapse

B Maitra, OB Akan - … on Molecular, Biological, and Multi-Scale …, 2024 - ieeexplore.ieee.org
The gut-brain axis is the communication link between the gut and the brain. Although it is
known that the gut-brain axis plays a pivotal role in homeostasis, its overall mechanism is …

Transcriptome sequencing reveals the promotion of apoptosis and M1 polarization of microglia under simulated microgravity

H Yu, XY Jia, LN Gao, T Huyan, JJ Gou, CL Gong… - Acta Astronautica, 2024 - Elsevier
The exponential progress in the field of space science and technology has facilitated the
prolonged habitation of astronauts in the space environment. However, the neurological and …