Most facets of mammalian physiology and behavior vary according to time of day, thanks to
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …

Due to advances in chronobiology, chronopharmacology, and global market constraints, the
traditional goal of pharmaceutics (eg design drug delivery systems with a constant drug …

Background Variation in blood pressure levels display circadian rhythms. The morning
surge in blood pressure is known to increase the risk of myocardial events in the first several …

Some specific features of the 24-hour blood pressure (BP) pattern are linked to the
progressive injury of target tissues and the triggering of cardiac and cerebrovascular events …

Abnormal nocturnal blood pressure (BP) dipping status may be partly determined by
nocturnal sympathetic activity. We studied the effect of nighttime dosing of an α1-adrenergic …

Resistant hypertension is defined as uncontrolled hypertension despite intensive treatment
with at least three antihypertensive agents, one of which ideally should be a diuretic. To …

Objective: To review evidence for dosing antihypertensives at bedtime and possible
cardiovascular risk reduction. Data Sources: A PubMed, EMBASE, and Cochrane Controlled …

In patients with hypertension, 24-hour blood pressure control is the major therapeutic goal.
The number of daily doses is one characteristic of an antihypertensive agent that may affect …

Biological functions and processes, including cardiovascular ones, exhibit significant
circadian (24-hour) and other period rhythms. Ambulatory blood pressure assessment …

Although much has been learned about circadian clocks and rhythms over the past few
decades, translation of this foundational science underlying the temporal regulation of …