Conspectus Bridged and fused rings are commonly found in biologically important
molecules. Current tactics to construct these ring systems are primarily based on stepwise …

In this review, synthetic and mechanistic aspects of key methodologies that exploit C–C
single-bond cleavage of strained ring systems are highlighted. The focus is on transition …

The cleavage and reorganization of carbon− carbon bonds is an industrial key technology
for crude oil refining, carried out on a massive scale. In contrast, C− C bond cleavage …

Transition-metal-catalyzed decarbonylation via carbon–carbon bond cleavage is an
essential synthetic methodology. Given the ubiquity of carbonyl compounds, the selective …

The transition-metal-catalyzed “cut and sew” transformation has recently emerged as a
useful strategy for preparing complex molecular structures. After oxidative addition of a …

Conventional organic synthesis has been mainly based upon the reactivities of π-bonds and
polar σ-bonds. Carbon–carbon single bonds are nonpolar and generally far less reactive …

C− C bond activation has emerged as an increasingly useful approach for constructing
complex molecular scaffolds through unusual bond-disconnection strategies. As a common …

A nickel/N‐heterocyclic carbene catalytic system has been established for decarbonylative
borylation of amides with B2nep2 by C− N bond activation. This transformation shows good …

Here, we report a general catalytic manifold for the selective C–C bond scission of ketones
via the exploitation of the ligand-to-metal charge transfer (LMCT) excitation mode. Through a …

A Rh (I)-catalyzed formal carbene insertion into C–C bond of benzocyclobutenols has been
realized by employing diazoesters as carbene precursors. The product indanol derivatives …