East Asia expert opinion on treatment initiation for chronic hepatitis B

JH Kao, TH Hu, J Jia, M Kurosaki… - Alimentary …, 2020 - Wiley Online Library
Background Globally, chronic hepatitis B (CHB) is a major public health concern. Timely and
effective management can prevent disease progression to cirrhosis and reduce the risk of …

[HTML][HTML] Development of hepatocellular carcinoma in treated and untreated patients with chronic hepatitis B virus infection

CL Lin, JH Kao - Clinical and Molecular Hepatology, 2023 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) is responsible for more than 50% of hepatocellular carcinoma (HCC)
in HBV hyperendemic areas, such as the Asia-Pacific region. Several hepatitis B viral factors …

Natural history and hepatocellular carcinoma risk in untreated chronic hepatitis B patients with indeterminate phase

DQ Huang, X Li, MH Le, AK Le, YH Yeo… - Clinical …, 2022 - Elsevier
Background & Aims Many patients with chronic hepatitis B (CHB) may not conform to any of
the defined phases and hence are classified as indeterminate. We aimed to characterize the …

Increasing on-treatment hepatocellular carcinoma risk with decreasing baseline viral load in HBeAg-positive chronic hepatitis B

WM Choi, GA Kim, J Choi, S Han… - The Journal of Clinical …, 2022 - Am Soc Clin Investig
BACKGROUND It is unclear whether the level of serum hepatitis B virus (HBV) DNA at
baseline affects the on-treatment risk of hepatocellular carcinoma (HCC) in hepatitis B e …

[PDF][PDF] Presence of liver inflammation in Asian patients with chronic hepatitis B with normal ALT and detectable HBV DNA in absence of liver fibrosis

J Liu, J Wang, X Yan, R Xue, J Zhan… - Hepatology …, 2022 - Wiley Online Library
Liver biopsies are recommended to exclude significant liver inflammation in patients with
chronic hepatitis B (CHB) with elevated HBV DNA but without other indications for antiviral …

Impact of expanding hepatitis B treatment guidelines: a modelling and economic impact analysis

YS Lim, SH Ahn, JJ Shim, H Razavi… - Alimentary …, 2022 - Wiley Online Library
Background Antiviral treatment in patients with chronic hepatitis B (CHB) may decrease the
risk of hepatocellular carcinoma (HCC) and death. However, only 2.2% of CHB patients …

Increased risk of hepatocellular carcinoma and mortality in chronic viral hepatitis with concurrent fatty liver

MN Kim, K Han, J Yoo, SG Hwang… - Alimentary …, 2022 - Wiley Online Library
Background Population‐based data are lacking regarding whether fatty liver is a risk factor
for hepatocellular carcinoma (HCC) and mortality in patients with chronic viral hepatitis. Aim …

Evidence for benefits of early treatment initiation for chronic hepatitis B

YS Lim, WR Kim, D Dieterich, JH Kao, JF Flaherty… - Viruses, 2023 - mdpi.com
Chronic hepatitis B (CHB) is the most common cause of hepatocellular carcinoma (HCC)
worldwide. Antiviral treatment reduces the risk of HCC and mortality; nonetheless, globally in …

Diabetic MAFLD is associated with increased risk of hepatocellular carcinoma and mortality in chronic viral hepatitis patients

MN Kim, K Han, J Yoo, SG Hwang… - … Journal of Cancer, 2023 - Wiley Online Library
Metabolic dysfunction‐associated fatty liver disease (MAFLD) can coexist with chronic viral
hepatitis. MAFLD is a heterogeneous disease because the diagnostic criteria include …

Cost-effectiveness of antiviral treatment in adult patients with immune-tolerant phase chronic hepatitis B

HL Kim, GA Kim, JA Park, HR Kang, EK Lee, YS Lim - Gut, 2021 - gut.bmj.com
Objective The cost-effectiveness of antiviral treatment in adult immune-tolerant (IT) phase
chronic hepatitis B (CHB) patients is uncertain. Design We designed a Markov model to …