Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Cutaneous fibrosis results from suboptimal wound healing following significant tissue injury
such as severe burns, trauma, and major surgeries. Pathologic skin fibrosis results in scars …

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in
children. NAFLD has emerged to be extremely prevalent, and predicted by obesity and male …

Objective Liver fibrosis is associated with significant collagen-I deposition largely produced
by activated hepatic stellate cells (HSCs); yet, the link between hepatocyte damage and the …

Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after
severe injury caused by autoimmune reactions, mechanical stress or infections. The …

Drug‐induced liver injury (DILI) is a major concern for patients, care givers and the
pharmaceutical industry. Interpretation of the serum biomarkers routinely used to detect and …

High-mobility group box 1 (HMGB1) is an abundant architectural chromosomal protein that
has multiple biologic functions: gene transcription, DNA replication, DNA-damage repair …

Damage-associated molecular pattern (DAMP) molecules are essential for the initiation of
innate inflammatory responses to infection and injury. The prototypic DAMP molecule, high …

The receptor for advanced glycation endproducts (RAGE) is a multiligand receptor and
member of the immunoglobulin superfamily. RAGE is mainly involved in tissue damage and …

High‐mobility group box 1 (HMGB1) is originally identified as a DNA‐binding protein that
functions as a structural co‐factor critical for proper transcriptional regulation in somatic …