Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …

The current COVID-19 pandemic is one of the most devastating events in recent history. The
virus causes relatively minor damage to young, healthy populations, imposing life …

Kidney disease represents a serious global health problem. One of the main concerns is its
late diagnosis, only feasible in a progressed disease state. The lack of a clinical …

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-
stage renal disease. The natural history of DKD includes glomerular hyperfiltration …

Pyroptosis is a novel inflammatory form of regulated cell death (RCD), characterized by cell
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …

Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted
to become by 2040 the fifth global cause of death. CKD is characterized by increased …

Rhubarb, in the form of a traditional Chinese medicine, is used in the treatment of chronic
kidney disease (CKD). Previous studies have demonstrated that Rhubarb possesses a good …

Obstructive nephropathy favors the progression to chronic kidney disease (CKD), a severe
health problem worldwide. The unilateral ureteral obstruction (UUO) model is used to study …

Prostaglandin E2 (PGE2) is one of the most abundant prostaglandins and has been
implicated in various diseases. Here, we aimed to explore the role of the PGE2 pathway in …

Renal fibrosis is a common feature of chronic kidney disease (CKD), and can lead to the
destruction of normal renal structure and loss of kidney function. Little progress has been …