Human plasma proteome during normal pregnancy

AL Tarca, R Romero, G Bhatti, F Gotsch… - Journal of proteome …, 2022 - ACS Publications
The human plasma proteome is underexplored despite its potential value for monitoring
health and disease. Herein, using a recently developed aptamer-based platform, we profiled …

Circulating chemerin is elevated in women with preeclampsia

LA Bartho, M Kandel, SP Walker, CA Cluver… - …, 2023 - academic.oup.com
Background: Preeclampsia is a severe complication of pregnancy. Chemerin is an
adipokine secreted from adipose tissue and highly expressed in placenta. This study …

A disintegrin and metalloproteinase 12 (ADAM12) is reduced at 36 weeks' gestation in pregnancies destined to deliver small for gestational age infants

F Andres, GP Wong, SP Walker, TM MacDonald… - Placenta, 2022 - Elsevier
First trimester circulating ADAM12 is reduced in fetal growth restriction (FGR) and
preeclampsia. We measured plasma ADAM12 at 36 weeks' gestation preceding diagnosis …

Serum DLK1 During Minipuberty and Pubertal Transition in Healthy Girls and in Girls with Precocious Puberty

L Vilmann, K Sørensen, AS Busch… - The Journal of …, 2024 - academic.oup.com
Context Delta-like non-canonical notch ligand 1 (DLK1) is negatively associated with
bodyweight. DLK1 pathogenic variants cause central precocious puberty (CPP) and obesity …

Fluoride-related changes in the fetal cord blood proteome; a pilot study

ST Tuomivaara, SJ Fisher, SC Hall, DE Goin… - Environmental …, 2024 - Springer
Background Fluoride exposure during pregnancy has been associated with various effects
on offspring, including changes in behavior and IQ. To provide clues to possible …

Pregnancy serum DLK1 concentrations are associated with indices of insulin resistance and secretion

CJ Petry, KA Burling, P Barker… - The Journal of …, 2021 - academic.oup.com
Context Delta like noncanonical notch ligand 1 (DLK1) is a paternally expressed imprinted
gene that encodes an epidermal growth factor repeat-containing transmembrane protein. A …

Low maternal DLK1 levels at 26 weeks is associated with small for gestational age at birth

A Pham, D Mitanchez, A Forhan, L Perin… - Frontiers in …, 2022 - frontiersin.org
Detecting SGA (small for gestational age) during pregnancy improves the fetal and neonatal
prognosis. To date, there is no valid antenatal biomarker of SGA used in clinical practice …

[Retracted] Analysis of Causes and Results of Fetal Growth in Utero Caused by Genetic Factors Detected by Ultrasound

M Yu, Y Liu, L Wang - Contrast Media & Molecular Imaging, 2022 - Wiley Online Library
In order to investigate the value of the ultrasonic monitoring of maternal and fetal vascular
parameters, serum vitamin D, and placental growth factor (PLGF) in predicting fetal growth …

Screening of patients born small for gestational age with the Silver-Russell syndrome phenotype for DLK1 variants

A Pham, ML Sobrier, E Giabicani… - European Journal of …, 2021 - nature.com
Silver–Russell syndrome (SRS) is a rare imprinting disorder associated with prenatal and
postnatal growth retardation. Loss of methylation (LOM) on chromosome 11p15 is observed …

Disturbed trophoblast transition links preeclampsia progression from placenta to the maternal syndrome

O Nonn, O Debnath, DS Valdes, K Sallinger… - bioRxiv, 2022 - biorxiv.org
Pre-eclampsia (PE) is a syndrome that affects multiple organ systems and is the most severe
hypertensive disorder in pregnancy. It frequently leads to preterm delivery, maternal and …