The potential of CD31 as a therapeutic target in atherosclerosis has been considered ever
since its cloning in the 1990s, but the exact role played by this molecule in the biologic …

Hematopoiesis involves an elaborate regulatory network of transcription factors that
coordinates the expression of multiple downstream genes, and maintains homeostasis …

Glioblastomas (GBMs) are highly vascular and lethal brain tumors that display cellular
hierarchies containing self-renewing tumorigenic glioma stem cells (GSCs). Because GSCs …

Recent work has established that heterozygous germline GATA2 mutations predispose
carriers to familial myelodysplastic syndrome (MDS)/acute myeloid leukemia …

The vascular endothelium plays a crucial role in regulating normal blood vessel physiology.
The gene products responsible are commonly expressed exclusively, or preferentially, in …

Ganglioside biosynthesis is strictly regulated by the activities of glycosyltransferases and is
necessarily controlled at the levels of gene transcription and posttranslational modification …

Advanced prostate cancer is a classic example of the intractability and consequent lethality
that characterizes metastatic carcinomas. Novel treatments have improved the survival of …

The membrane-bound mucins belong to an ever-increasing family of O-glycoproteins.
Based on their structure and localization at the cell surface they are thought to play important …

Endoglin (CD105) is a cell surface component of the transforming growth factor-β (TGF-β)
receptor complex highly expressed by endothelial cells. Mutations in the endoglin gene are …

The receptor tyrosine kinase Flk-1 is essential for embryonic blood vessel development and
for tumor angiogenesis. To identify upstream transcriptional regulators of Flk-1, the gene …