Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are
members of the nuclear receptor superfamily that mainly act as ligand-activated transcription …

Abstract Pregnane X receptor (PXR, NR1I2) is a prototypical member of the nuclear receptor
superfamily. PXR can be activated by both endobiotics and xenobiotics. As a key xenobiotic …

Pregnane X receptor (PXR, NR1I2), a prototypical member of the nuclear receptor
superfamily, has been implicated in various processes including metabolism, immune …

Both aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) belong among key
regulators of xenobiotic metabolism in the intestinal tissue. AhR in particular is activated by a …

Primary biliary cholangitis (PBC) is an autoimmune liver disease characterised by the
immune-mediated destruction of small and medium intrahepatic bile ducts, with variable …

Pregnane X receptor (PXR), a nuclear receptor known for modulating the transcription of
drug metabolizing enzymes and transporters (DMETs), such as cytochrome P450 3A4 and P …

Leydig cells (LCs) in the testes produce the male sex hormone testosterone (T). Several
xenobiotics, including clinical drugs, supplements, and environmental chemicals, are known …

As the first oral multi-target anti-tumor drug proved for the treatment of patients with
advanced liver cancer in 2007, sorafenib has changed the landscape of advanced …

Methods The expression profile of PXR-cytochrome p450 3A4 (CYP3A4) signaling was
determined by PCR, western blotting, and tissue microarray. Cell viability and aflatoxin B1 …

Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor that plays a key role in
drug metabolism. Recently, PXR was found to attenuate the development of liver cancer by …