Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for
the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR …

Adipose tissue is a complex, multicellular organ that profoundly influences the function of
nearly all other organ systems through its diverse metabolite and adipokine secretome …

Lipid droplet (LD) lipolysis in brown adipose tissue (BAT) is generally considered to be
required for cold-induced nonshivering thermogenesis. Here, we show that mice lacking …

Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD)
organelles by professional storage cells called adipocytes. These lipids are mobilized …

The molecular mediator and functional significance of meal-associated brown fat (BAT)
thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non …

Excess caloric intake can lead to insulin resistance. The underlying reasons are complex but
likely related to ectopic lipid deposition in nonadipose tissue. We hypothesized that the …

Adipose tissue, when carried around in excessive amounts, predisposes to a large number
of diseases. Epidemiological data show that the prevalence of obesity has significantly …

Chronic activation of β3-adrenergic receptors (β3-ARs) expands the catabolic activity of both
brown and white adipose tissue by engaging uncoupling protein 1 (UCP1)-dependent and …