Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

J Liu, Q Xiao, J Xiao, C Niu, Y Li, X Zhang… - Signal transduction and …, 2022 - nature.com
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

Genetic advances in chronic obstructive pulmonary disease. Insights from COPDGene

MF Ragland, CJ Benway, SM Lutz… - American journal of …, 2019 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that
is influenced by both genetic and environmental factors. For many years, knowledge of the …

Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics

JJ Partanen, P Häppölä, W Zhou, AA Lehisto, M Ainola… - Cell genomics, 2022 - cell.com
The research of rare and devastating orphan diseases, such as idiopathic pulmonary
fibrosis (IPF) has been limited by the rarity of the disease itself. The prognosis is poor—the …

Future research directions in pneumonia. NHLBI working group report

CS Dela Cruz, RG Wunderink… - American journal of …, 2018 - atsjournals.org
Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although
triggered by a pathogen, pneumonia often results from dysregulations of host defense that …

Large‐scale plasma proteomics can reveal distinct endotypes in chronic obstructive pulmonary disease and severe asthma

M Suzuki, JJ Cole, S Konno, H Makita… - Clinical and …, 2021 - Wiley Online Library
Background Chronic airway diseases including chronic obstructive pulmonary disease
(COPD) and asthma are heterogenous in nature and endotypes within are underpinned by …

Inhaled Corticosteroids in Subjects with Chronic Obstructive Pulmonary Disease: An Old, Unfinished History

AS Melani, S Croce, G Fabbri, M Messina, E Bargagli - Biomolecules, 2024 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is one of the major causes of disability and
death. Maintenance use of inhaled bronchodilator (s) is the cornerstone of COPD …

[HTML][HTML] Host genetic effects in pneumonia

HH Chen, DM Shaw, LE Petty, M Graff… - The American Journal of …, 2021 - cell.com
Given the coronavirus disease 2019 (COVID-19) pandemic, investigations into host
susceptibility to infectious diseases and downstream sequelae have never been more …

Coronary artery disease associated gene Phactr1 modulates severity of vascular calcification in vitro

R Aherrahrou, Z Aherrahrou, H Schunkert… - … and biophysical research …, 2017 - Elsevier
Calcification of vessels is strongly associated with atherosclerosis and leads to coronary
artery disease (CAD) and myocardial infarction (MI). Genome-wide association studies …

Exploring the cross-phenotype network region of disease modules reveals concordant and discordant pathways between chronic obstructive pulmonary disease and …

A Halu, S Liu, SH Baek, BD Hobbs… - Human molecular …, 2019 - academic.oup.com
Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are
two pathologically distinct chronic lung diseases that are associated with cigarette smoking …

[HTML][HTML] Variants in the β-globin locus are associated with pneumonia in African American children

NLN Halligan, SC Hanks, K Matsuo, T Martins… - Human Genetics and …, 2025 - cell.com
Summary In African American adults, the strongest genetic predictor of pneumonia appears
to be the A allele of rs334, a variant in the β-globin gene, which in homozygous form causes …