Diabetes is an important risk factor for the development of cardiovascular disease including
atherosclerosis and ischemic heart disease. Vascular complications including macro-and …

Continuous cerebral blood flow is essential for neuronal survival, but whether vascular tone
influences resting neuronal function is not known. Using a multidisciplinary approach in both …

Extracellular ATP interacts with purinergic type 2 (P2) receptors and elicits many crucial
biological functions. Extracellular ATP is sequentially hydrolyzed to ADP and AMP by the …

Purinergic receptors play a central role in the renal pathophysiology of angiotensin II-
induced hypertension, since elevated ATP chronically activates P2X7 receptors in this …

Polycystic kidney diseases (PKDs) are a group of inherited nephropathies marked by
formation of fluid-filled cysts along the nephron. Growing evidence suggests that in the …

Highlights•Renal distribution of P2 purinoceptors in vascular, glomerular and tubular
structures.•P2 receptors are important for renal autoregulation and for regulation of renal …

Proper renal blood flow (RBF) and glomerular filtration rate (GFR) are critical for maintaining
normal blood pressure, kidney function and water and electrolyte homeostasis. The renal …

Glomerular arteriolar vasoconstriction and tubulointerstitial injury are observed before
glomerular damage occurs in models of hypertension. High interstitial ATP concentrations …

The renal handling of Na+ balance is a major determinant of the blood pressure (BP) level.
The inability of the kidney to excrete the daily load of Na+ represents the primary cause of …

Renal autoregulation is critical in maintaining stable renal blood flow (RBF) and glomerular
filtration rate (GFR). Renal ischemia-reperfusion (IR)-induced kidney injury is characterized …