Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: Relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior

RP Patrick, BN Ames - The FASEB Journal, 2015 - Wiley Online Library
Serotonin regulates a wide variety of brain functions and behaviors. Here, we synthesize
previous findings that serotonin regulates executive function, sensory gating, and social …

Sphingolipids: membrane microdomains in brain development, function and neurological diseases

ASB Olsen, NJ Færgeman - Open biology, 2017 - royalsocietypublishing.org
Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …

[HTML][HTML] Molecular dynamics simulations of GPCR–cholesterol interaction: An emerging paradigm

D Sengupta, A Chattopadhyay - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
G protein-coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across cell membranes and represent major targets in the development of …

Cholesterol interaction motifs in G protein‐coupled receptors: Slippery hot spots?

P Sarkar, A Chattopadhyay - Wiley Interdisciplinary Reviews …, 2020 - Wiley Online Library
G protein‐coupled receptors (GPCRs) are cell membrane associated signaling hubs that
orchestrate a multitude of cellular functions upon binding to a diverse variety of extracellular …

Exploring GPCR–lipid interactions by molecular dynamics simulations: excitements, challenges, and the way forward

D Sengupta, X Prasanna, M Mohole… - The Journal of …, 2018 - ACS Publications
Gprotein-coupled receptors (GPCRs) are seven transmembrane receptors that mediate a
large number of cellular responses and are important drug targets. One of the current …

GPCRs: Lipid‐dependent membrane receptors that act as drug targets

A Chattopadhyay - Advances in Biology, 2014 - Wiley Online Library
G protein‐coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across cell membranes and represent major targets in the development of …

Insights into the role of membrane lipids in the structure, function and regulation of integral membrane proteins

K Renard, B Byrne - International journal of molecular sciences, 2021 - mdpi.com
Membrane proteins exist within the highly hydrophobic membranes surrounding cells and
organelles, playing key roles in cellular function. It is becoming increasingly clear that the …

Functional characterization of putative cholesterol binding sequence (CRAC) in human type‐1 cannabinoid receptor

S Oddi, E Dainese, F Fezza, M Lanuti… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 116, 858–865. Abstract Endocannabinoid signaling modulates a
variety of neuroinflammatory and neurodegenerative diseases, mainly through the activation …

Membrane lipids in the function of serotonin and adrenergic receptors

M Jafurulla, A Chattopadhyay - Current Medicinal Chemistry, 2013 - ingentaconnect.com
G-protein coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across membranes, and represent major targets in the development of novel …

Changes in membrane sphingolipid composition modulate dynamics and adhesion of integrin nanoclusters

C Eich, C Manzo, S Keijzer, GJ Bakker… - Scientific reports, 2016 - nature.com
Sphingolipids are essential constituents of the plasma membrane (PM) and play an
important role in signal transduction by modulating clustering and dynamics of membrane …