The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Cardiovascular disease and infections are directly or indirectly associated with an altered
immune response, which leads to a high incidence of morbidity and mortality, and together …

Good nutrition could maintain health and life. Polyphenols are common nutrient mainly
derived from fruits, vegetables, tea, coffee, cocoa, mushrooms, beverages, and traditional …

Cardiovascular disease and infections are major causes for the high incidence of morbidity
and mortality of patients with chronic kidney disease. Both complications are directly or …

Innate immunity and chronic inflammation are involved in atherosclerosis and
atherothrombosis, leading to target organ damage in essential hypertension (EH). However …

Background—Angiotensin II (ATII), a potent vasoconstrictor, causes hypertension, promotes
infiltration of myelomonocytic cells into the vessel wall, and stimulates both vascular and …

Abstract Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1
receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium …

Observational clinical and ex vivo studies have established a strong association between
atrial fibrillation and inflammation. However, whether inflammation is the cause or the …

There is increasing evidence that Angiotensin II (AngII), a major regulator of blood pressure
and cardiovascular homeostasis, is involved in the regulation of cell proliferation …

Background—Acute aortic dissection (AAD) is a life-threatening vascular disease without
effective pharmaceutical therapy. Matrix metalloproteinases (MMPs) are implicated in the …