By the introduction of technological advancement in methods of structural analysis,
electronics, and recombinant DNA techniques, research in physiology has become …

Local intracellular Ca2+ transients, termed Ca2+ sparks, are caused by the coordinated
opening of a cluster of ryanodine-sensitive Ca2+ release channels in the sarcoplasmic …

Updated to reflect the newest changes in genetics, Thompson & Thompson's Genetics in
Medicine returns as one of the most favored texts in this fascinating and rapidly evolving …

The RYR1 gene encodes the skeletal muscle isoform ryanodine receptor and is
fundamental to the process of excitation–contraction coupling and skeletal muscle calcium …

Calcium-induced calcium release (CICR) was first discovered in skeletal muscle. CICR is
defined as Ca2+ release by the action of Ca2+ alone without the simultaneous action of …

MALIGNANT hyperthermia (MH) is a potentially lethal condition in which sustained muscle
contracture, with attendant hypercatabolic reactions and elevation in body temperature, are …

It is 30 yr since the British Journal of Anaesthesia published the first consensus protocol for
the laboratory diagnosis of malignant hyperthermia susceptibility from the European …

Malignant hyperthermia susceptibility (MHS) is characterized by genetic heterogeneity.
However, except for the MHS1 locus, which corresponds to the skeletal muscle ryanodine …

Skeletal muscles are most often examined at the cellular level in relationship to their primary
role in force generation. Throughout the animal kingdom, regardless of phylogeny, muscle …

Central core disease (CCD) is a morphologically distinct, autosomal dominant myopathy
with variable clinical features. A close association with malignant hypertheria (MH) has been …