The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …

One of the current stumbling blocks in our fight against cancer is the development of
acquired resistance to therapy, which is attributable to approximately 90% of cancer-related …

The liver is often thought of as a single functional unit, but both its structural and functional
architecture make it highly multivalent and adaptable. In any given physiological situation …

Histone methylation is a key posttranslational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …

Males and females differ in body composition and fat distribution. Using a mouse model that
segregates gonadal sex (ovaries and testes) from chromosomal sex (XX and XY), we …

Iron metabolism is closely associated with the pathogenesis of obesity. However, the
mechanism of the iron-dependent regulation of adipocyte differentiation remains unclear …

Lysine-specific demethylase 5A (KDM5A, also named RBP2 or JARID1A) is a demethylase
that can remove methyl groups from histones H3K4me1/2/3. It is aberrantly expressed in …

Sex is a key risk factor for many types of cardiovascular disease. It is imperative to
understand the mechanisms underlying sex differences to devise optimal preventive and …