The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1, 5-disubstituted 1, 2,
3-triazoles in one step and complements the more established copper-catalyzed reaction …

Although many cellular processes depend upon enzymatic reactions, protein–protein
interactions (PPIs) mediate a large number of important regulatory pathways and thus play a …

Conspectus Foldamers have defined and predictable structures, improved resistance to
proteolytic degradation, enhanced chemical diversity, and are versatile in their mimicry of …

Although interest in stabilized α-helical peptides as next-generation therapeutics for
modulating biomolecular interfaces is increasing, peptides have limited functionality and …

The use of peptidomimetic scaffolds is a promising strategy for the inhibition of protein–
protein interactions (PPIs). Herein, we demonstrate that sulfono-γ-AApeptides can be …

The past 20 years have witnessed an impressive expansion of the 'drug space'; defined as
the intersection of the Medicinal Chemistry space and the Biologically Active space relevant …

An interruption in Aβ homeostasis leads to the deposit of neurotoxic amyloid plaques and is
associated with Alzheimer's disease. A supramolecular strategy based on the assembly of …

Inhibition of protein–protein interactions (PPIs) represents a major challenge in chemical
biology and drug discovery. α‐Helix mediated PPIs may be amenable to modulation using …

We describe a novel fragment library termed fragments of life (FOL) for structure-based drug
discovery. The FOL library includes natural small molecules of life, derivatives thereof, and …

Blocking protein-protein interactions (PPI) using small molecules or peptides modulates
biochemical pathways and has therapeutic significance. PPI inhibition for designing drug …