Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy
A Vezzani, S Balosso, T Ravizza - Nature Reviews Neurology, 2019 - nature.com
Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …
generation of seizures. The pathogenic processes of seizure generation and recurrence are …
[HTML][HTML] Recent developments on PET radiotracers for TSPO and their applications in neuroimaging
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward
TR Guilarte - Pharmacology & therapeutics, 2019 - Elsevier
Abstract The use of Translocator Protein 18 kDa (TSPO) as a clinical neuroimaging
biomarker of brain injury and neuroinflammation has increased exponentially in the last …
biomarker of brain injury and neuroinflammation has increased exponentially in the last …
A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis
E Nutma, JA Stephenson, RP Gorter, J de Bruin… - Brain, 2019 - academic.oup.com
The 18 kDa translocator protein (TSPO) is increasingly used to study brain and spinal cord
inflammation in degenerative diseases of the CNS such as multiple sclerosis. The enhanced …
inflammation in degenerative diseases of the CNS such as multiple sclerosis. The enhanced …
[HTML][HTML] Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication
Current medical countermeasures for organophosphate (OP)-induced status epilepticus
(SE) are not effective in preventing long-term morbidity and there is an urgent need for …
(SE) are not effective in preventing long-term morbidity and there is an urgent need for …
[HTML][HTML] Microglia in epilepsy
C Yu, X Deng, D Xu - Neurobiology of Disease, 2023 - Elsevier
Epilepsy is one of most common chronic neurological disorders, and the antiseizure
medications developed by targeting neurocentric mechanisms have not effectively reduced …
medications developed by targeting neurocentric mechanisms have not effectively reduced …
A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity
While the dire cardiometabolic consequences of the hypercaloric modern 'Western'diet are
well known, there is not much information on the health impact of a high sucrose diet not …
well known, there is not much information on the health impact of a high sucrose diet not …
Ferrostatin-1 mitigates cognitive impairment of epileptic rats by inhibiting P38 MAPK activation
Q Ye, C Zeng, C Luo, Y Wu - Epilepsy & Behavior, 2020 - Elsevier
Evidence indicates that ferrostain-1 (Fer-1), a specific inhibitor of ferroptosis, could
ameliorate cognitive dysfunction of rats with kainic acid (KA)-induced temporal lobe epilepsy …
ameliorate cognitive dysfunction of rats with kainic acid (KA)-induced temporal lobe epilepsy …
[HTML][HTML] Microglia as therapeutic target in central nervous system disorders
O Fatoba, T Itokazu, T Yamashita - Journal of Pharmacological Sciences, 2020 - Elsevier
Chronic microglial activation is associated with the pathogenesis of several CNS disorders.
Microglia show phenotypic diversity and functional complexity in diseased CNS. Thus …
Microglia show phenotypic diversity and functional complexity in diseased CNS. Thus …
PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study
Abstract Background Cyclooxygenase-2 (COX-2), which is rapidly upregulated by
inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several …
inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several …