The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …

Whitehead Institute for Biomedical Research Massachusetts Institute of Technology
Cambridge, Massachusetts 02142 pRB, the product of the retinoblastoma tumor suppressor …

In mammalian cells, the decision to proliferate is thought to be irreversibly made at the
restriction point of the cell cycle,, when mitogen signalling engages a positive feedback loop …

Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

▪ Abstract The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of
cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase …

Since its discovery as a CDKI (cyclin-dependent kinase inhibitor) in 1993, the tumor
suppressor p16 (INK4A/MTS-1/CDKN2A) has gained widespread importance in cancer. The …

The E2F transcription factor family determines whether or not a cell will divide by controlling
the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct …

Although a number of transfection experiments have suggested potential targets for the
action of the E2F1 transcription factor, as is the case for many transcriptional regulatory …

A key event in the regulation of eukaryotic gene expression is the posttranslational
modification of nucleosomal histones, which converts regions of chromosomes into …

E2F transcription activity is composed of a family of heterodimers encoded by distinct genes.
Through the overproduction of each of the five known E2F proteins in mammalian cells, we …