The widely accepted model of G protein‐coupled receptor (GPCR) regulation describes a
system where the agonist‐activated receptors couple to G proteins to induce a cellular …

Elucidation of the molecular mechanisms underlying G protein-coupled receptor (GPCR)
dephosphorylation remains a major challenge. While specific GPCR phosphatases (GRPs) …

The melanocortin-2 (MC2) receptor accessory protein (MRAP) is required for trafficking of
the G protein-coupled MC2 receptor to the plasma membrane. The mechanism of action and …

Summary Phosphoinositide 3-kinase γ (PI3Kγ) is activated by G protein-coupled receptors
(GPCRs). We show here that PI3Kγ inhibits protein phosphatase 2A (PP2A) at the β …

In vitro cultures of two nematodes (Caenorhabditis elegans and Ascaris suum) were
established to study the nematicidal activity of three monoterpenoids (thymol, carvacrol and …

Lysophosphatidylcholine has been shown to enhance neutrophil functions through a
mechanism involving the G protein-coupled receptor G2A. Recent data support an indirect …

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs),
which constitute the largest family of membrane proteins, mediate responses to diverse …

Thyrotropin-releasing hormone (TRH) is an important endocrine agent that regulates the
function of cells in the anterior pituitary and the central and peripheral nervous systems. By …

The pituitary receptor for thyrotropin-releasing hormone (TRH) is a calcium-mobilizing G
protein-coupled receptor (GPCR) that signals through Gq/11, elevating calcium, and …

Type 1 parathyroid hormone receptor (PTH1R) activation, desensitization, internalization,
and recycling proceed in a cyclical manner. The Na+/H+ exchange regulatory factor 1 …